Valaciclovir Nitroso Impurity 1은 발라시클로비르의 제조 및 분해 경로와 연관된 니트로소 유래 공정 관련 불순물로, 분자식은 C5H4N6O2이며 분자량은 180.1 g/mol이다. 이 구조는 니트로사민 계열 물질의 가능성과 부합하며, 해당 화학군은 ICH M7 원칙과 최신 니트로사민 위험평가에서 변이원성 및 유전독성 관점으로 엄격하게 검토된다. 생성은 아민 함유 중간체에 대한 니트로소화 조건 또는 저장 중의 2차 전환에서 기인할 수 있다. 극미량 정량에는 일반적으로 LC-MS/MS, 고분해능 질량분석, 그리고 직교 크로마토그래피가 요구된다.
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