1-(2-Methoxyphenoxy)-3-(2-methoxyphenylamino)propan-2-ol, C17H21NO4, mit einer Molekülmasse von 303,35 g/mol, ist ein sekundärer Aminoalkohol mit zwei anisylischen Etherfunktionen und einem chiralen Hydroxypropylgerüst. Die Struktur spricht für eine prozessbedingte Verunreinigung oder ein synthetisches Zwischenprodukt, das aus unvollständigen O-Arylierungs- oder N-Alkylierungsschritten beziehungsweise aus Umlagerungen während der mehrstufigen Herstellung verwandter Aryloxypropanolamine hervorgeht. Aufgrund des polaren, ionisierbaren Profils sind zur Spurencharakterisierung in der Regel LC-MS/MS, ergänzend LC-HRMS sowie orthogonale HPLC-UV- oder GC-MS-Verfahren nach Derivatisierung erforderlich. Für die regulatorische Bewertung sind Herkunft, relativer Ansprechfaktor und mögliche Mitübertragung in den Wirkstoff relevant.
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