Cefaclor EP Impurity D, auch als Cefaclor-Delta-3-Isomer bezeichnet, ist ein Strukturisomer des Cephalosporin-Antibiotikums Cefaclor und keine eigenständige heterozyklische Stoffklasse. Die CAS-Nummer 152575-13-8 kennzeichnet diese verwandte Substanz mit der Summenformel C15H14ClN3O4S und einer Molmasse von 367,80 g/mol. Das Nebenprodukt ist mit einer Isomerisierung während der Synthese oder Lagerung vereinbar, bei der innerhalb des Cephem-Gerüsts eine Umlagerung der Doppelbindungsposition erfolgt, ohne die Elementzusammensetzung zu verändern. Für die Identifizierung und Spurengehaltsbestimmung sind orthogonale Verfahren wie HPLC mit Diodenarray-Detektion, LC-MS/MS und gegebenenfalls NMR erforderlich, um die Positionsisomerie sicher zu unterscheiden.
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