Cefaclor EP Impurity D, also designated Cefaclor delta-3-isomer, is a structural isomer of the cephalosporin antibiotic cefaclor rather than a separate heterocyclic class. CAS 152575-13-8 identifies this related substance with molecular formula C15H14ClN3O4S and molecular weight 367.80 g/mol. The impurity is consistent with isomerization arising during synthesis or storage through rearrangement within the cephem nucleus, altering double-bond position without changing elemental composition. Its characterization typically requires orthogonal methods such as HPLC with diode-array detection, LC-MS/MS, and, when needed, NMR to resolve positional isomerism and trace-level quantification in pharmacopeial impurity profiling.
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