5-Bromo Keto THF Impurity (CAS 915095-84-0) ist eine halogenierte, aus Tetrahydrofuran abgeleitete Carbonylverunreinigung, die typischerweise als Nebenprodukt der Syntheseroute oder durch oxidative Degradation bromierter Zwischenstufen entsteht. Mit der Summenformel C17H14BrClO3 und einer Molekülmasse von 381,7 g/mol handelt es sich um eine strukturell modifizierte Spezies, deren Brom- und Chlorsubstituenten Retentionsverhalten und massenspektrometrische Komplexität erhöhen. Die Identifizierung und Quantifizierung erfordern üblicherweise RP-HPLC gekoppelt mit LC-MS/MS, ergänzt durch hochauflösende MS und, sofern die Flüchtigkeit ausreicht, GC-MS. Solche halogenierten Prozessverunreinigungen sind im Rahmen von ICH Q3A/Q3B und gegebenenfalls unter genotoxikologischen Aspekten zu bewerten.
References
“Empagliflozin: MedlinePlus Drug Information.†Medlineplus.gov, 2021, medlineplus.gov/druginfo/meds/a614043.html
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