Empagliflozin R-Furanose, CAS 1620758-31-7, ist eine strukturell isomere Verunreinigung des Natrium-Glukose-Cotransporter-2-Inhibitors Empagliflozin, die aus einer Ringsisomerisierung der Kohlenhydratkomponente in die Furanoseform hervorgeht. Mit der Summenformel C23H27ClO7 und einer Molmasse von 450,91 g/mol behält sie das chlorierte Arylsystem und das Arylglucosid-Motiv bei, zeigt jedoch eine veränderte stereochemische und stereoelektronische Topologie gegenüber dem therapeutischen Pyranosegerüst. Der Nachweis und die Quantifizierung erfolgen üblicherweise mittels LC-MS/MS und hochauflösender LC-MS, ergänzt durch NMR und HPLC mit chiraler oder RP-Trennung aufgrund der engen physikochemischen Verwandtschaft zum Wirkstoff.
References
Wanner, Christoph, et al. “Empagliflozin and Progression of Kidney Disease in Type 2 Diabetes.†New England Journal of Medicine, vol. 375, no. 4, July 2016, pp. 323–34, https://doi.org/10.1056/nejmoa1515920. ?Frampton, James E. “Empagliflozin: A Review in Type 2 Diabetes.†Drugs, vol. 78, no. 10, June 2018, pp. 1037–48, https://doi.org/10.1007/s40265-018-0937-z. ?
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