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62498-69-5Citalopram Didesmethyl Impurity (Free base)

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Katalog-Nr.::	VE006519
CAS-Nr.::	62498-69-5
Summenformel::	C18H17FN2O
Molare Masse::	296.37 g/mol

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Zusätzliche Informationen zu CAS 62498-69-5

Parent drug

Citalopram

IUPAC-Name

1-(3-Aminopropyl)-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile

Synonyme

N,N-DiDesmethyl Citalopram

Pharmacopeial Synonyms

N/A

SMILES

N#CC1=CC2=C(C(C3=CC=C(F)C=C3)(CCCN)OC2)C=C1

InChI

InChI=1S/C18H17FN2O/c19-16-5-3-15(4-6-16)18(8-1-9-20)17-7-2-13(11-21)10-14(17)12-22-18/h2-7,10H,1,8-9,12,20H2

Beschreibung

Citalopram Didesmethyl Impurity (Free base), N,N-DiDesmethyl Citalopram, CAS 62498-69-5, is a primary demethylation impurity encountered during citalopram synthesis and stability studies. Characterized by LC-MS and NMR, this basic impurity requires targeted method development for accurate quantitation in API batches and formulated products. Typical control strategies include optimization of methylation steps, purification by preparative HPLC, and validated stability-indicating assays to monitor its formation under acidic or oxidative conditions. Relevant analytical parameters include retention time, mass fragmentation pattern, and limit of quantitation within regulatory thresholds. Supplied as a certified reference material, it supports impurity profiling, method validation, and regulatory submissions.