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EsCitalopram N-Desmethyl (Free Base)

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Katalog-Nr.::	VE006634
CAS-Nr.::	N/A
Summenformel::	C19H19FN2O
Molare Masse::	310.4 g/mol

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Zusätzliche Informationen zu EsCitalopram N-Desmethyl (Free Base)

Parent drug

Escitalopram

IUPAC-Name

(S)-1-(4′-Fluorophenyl)-1-(3-(methylamino)propyl)-1, 3-dihydroisobenzo furan-5-carbonitrile

Synonyme

N/A

Beschreibung

It is one of impurity present in EsCitalopram, Escitalopram is a selective serotonin reuptake inhibitor, which enhances serotonergic activity by binding to the orthosteric binding site on the serotonin transporter, the same site to which endogenous 5-HT binds and thus prevents the reuptake of serotonin into the presynaptic neuron. It binds to a secondary allosteric site on the SERT molecule to inhibit 5-HT reuptake more. sustained elevation of synaptic 5HT eventually causes desensitization of 5-HT1A auto-receptors, which normally endogenous 5-HT release in the presence of excess 5-HT, this desensitization is needed for the clinical effect of SSRIs and is responsible for their typically prolonged onset of action

References

Landy, K., Rosani, A., & Estevez, R. (2022, October 9). Escitalopram. Retrieved November 4, 2022, from Nih.gov website: https://www.ncbi.nlm.nih.gov/books/NBK557734/