L-Tyrosin, auch bezeichnet als Levodopa EP Impurity B und Phenylalanine EP Impurity C, ist die aromatische Aminosäure 4-Hydroxy-L-phenylalanin (CAS 60-18-4) mit der Summenformel C9H11NO3 und einer Molmasse von 181.07 g/mol. Strukturell handelt es sich um ein para-hydroxylierter Phenylalanin-Derivat, das biogenetisch und abbaubedingt eng mit Catecholaminvorstufen verknüpft ist. Im pharmakopöischen Umfeld kann diese Spezies als prozessbedingte Verunreinigung oder als Folge unvollständiger Umsetzung sowie hydrolytischer oder oxidativer Umwandlung in Herstellungswegen von Levodopa und Phenylalanin auftreten. Die Identifizierung erfordert typischerweise LC-MS/MS, LC-UV und bei Spurenanalytik hochauflösende MS oder chirale LC.
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