Rosuvastatin-(6R)-Isomer-Calciumsalz, CAS 854898-49-0, ist eine stereochemische Verunreinigung des Statin-Wirkstoffs, bei der die Konfiguration am C6-Zentrum invertiert ist und somit ein Konfigurationsisomer statt eines Abbauprodukts vorliegt. Mit der Summenformel C22H27CaFN3O6S und einem Molekulargewicht von 520,6 g/mol liegt die Substanz als Calciumsalz vor und bewahrt das Pyrimidinyl-Sulfonamid-Pharmakophor, weshalb die Abtrennung vom Wirkstoff eine stereoselektive Trennung erfordert. Die Entstehung kann während der Synthese oder durch Epimerisierung unter sauren oder thermischen Bedingungen erfolgen. Die Bestimmung erfolgt üblicherweise mittels chiraler HPLC mit LC-MS/MS, ergänzt durch NMR.
References
Luvai, A., Mbagaya, W., Hall, A. S., & Barth, J. H. (2012). Rosuvastatin: A Review of the Pharmacology and Clinical Effectiveness in Cardiovascular Disease. Clinical Medicine Insights: Cardiology, 6, CMC.S4324. https://doi.org/10.4137/cmc.s4324
To provide the best experiences, we use technologies like cookies to store and/or access device information. Consenting to these technologies will allow us to process data such as browsing behavior or unique IDs on this site. Not consenting or withdrawing consent, may adversely affect certain features and functions.
Functional
Immer aktiv
The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network.
Preferences
The technical storage or access is necessary for the legitimate purpose of storing preferences that are not requested by the subscriber or user.
Statistics
The technical storage or access that is used exclusively for statistical purposes.The technical storage or access that is used exclusively for anonymous statistical purposes. Without a subpoena, voluntary compliance on the part of your Internet Service Provider, or additional records from a third party, information stored or retrieved for this purpose alone cannot usually be used to identify you.
Marketing
The technical storage or access is required to create user profiles to send advertising, or to track the user on a website or across several websites for similar marketing purposes.
To provide the best experiences, we use technologies like cookies to store and/or access device information. Consenting to these technologies will allow us to process data such as browsing behavior or unique IDs on this site. Not consenting or withdrawing consent, may adversely affect certain features and functions.
Functional
Immer aktiv
The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network.
Preferences
The technical storage or access is necessary for the legitimate purpose of storing preferences that are not requested by the subscriber or user.
Statistics
The technical storage or access that is used exclusively for statistical purposes.The technical storage or access that is used exclusively for anonymous statistical purposes. Without a subpoena, voluntary compliance on the part of your Internet Service Provider, or additional records from a third party, information stored or retrieved for this purpose alone cannot usually be used to identify you.
Marketing
The technical storage or access is required to create user profiles to send advertising, or to track the user on a website or across several websites for similar marketing purposes.
