Rosuvastatina sal de cálcio do isômero (6R), CAS 854898-49-0, é uma impureza estereoquímica da substância ativa estatínica na qual a inversão no centro C6 produz um isômero configuracional, e não um fragmento de degradação. Com fórmula molecular C22H27CaFN3O6S e massa molecular de 520.6 g/mol, mantém a forma de sal de cálcio e o farmacóforo pirimidinil sulfonamida, exigindo separação estereosseletiva para diferenciação do fármaco de origem. Sua formação pode ocorrer na síntese ou por epimerização sob estresse ácido ou térmico. A quantificação normalmente requer HPLC quiral acoplada a LC-MS/MS, com confirmação estrutural por RMN quando necessário.
Referências
Luvai, A., Mbagaya, W., Hall, A. S., & Barth, J. H. (2012). Rosuvastatin: A Review of the Pharmacology and Clinical Effectiveness in Cardiovascular Disease. Clinical Medicine Insights: Cardiology, 6, CMC.S4324. https://doi.org/10.4137/cmc.s4324
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