Rosuvastatin (6R)-Isomer Calcium Salt, CAS 854898-49-0는 로수바스타틴의 입체화학적 불순물로서, C6 중심의 반전에 의해 형성되는 구성 이성질체이며 분해 산물이 아니다. 분자식 C22H27CaFN3O6S, 분자량 520.6 g/mol을 가지며 칼슘염 형태와 pyrimidinyl sulfonamide 약리핵을 유지하므로 원약과의 구분에는 입체선택적 분리가 필요하다. 생성은 합성 과정 또는 산성 조건과 열 스트레스에서의 epimerization으로 발생할 수 있다. 정량에는 일반적으로 chiral HPLC와 LC-MS/MS가 요구되며, 구조 확인을 위해 NMR 보조 분석이 사용된다.
References
Luvai, A., Mbagaya, W., Hall, A. S., & Barth, J. H. (2012). Rosuvastatin: A Review of the Pharmacology and Clinical Effectiveness in Cardiovascular Disease. Clinical Medicine Insights: Cardiology, 6, CMC.S4324. https://doi.org/10.4137/cmc.s4324
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