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New Jersey, USA
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Mumbai, India

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Rosuvastatin Dehydro Acid

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Katalog-Nr.::	VE0026554
CAS-Nr.::	N/A
Summenformel::	C22H26FN3O5S
Molare Masse::	463.5 g/mol

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Zusätzliche Informationen zu

Parent drug

Rosuvastatin

IUPAC-Name

(2E,5R,6E)-7-[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-propan-2-ylpyrimidin-5-yl]-5-hydroxyhepta-2,6-dienoic acid

Pharmacopeial Synonyms

N/A

Synonyme

(2E,5R,6E)-3-Dehydroxy Rosuvastatin

SMILES

CC(C)C1=NC(=NC(=C1/C=C/[C@@H](C/C=C/C(=O)O)O)C2=CC=C(C=C2)F)N(C)S(=O)(=O)C

InChI

InChI=1S/C22H26FN3O5S/c1-14(2)20-18(13-12-17(27)6-5-7-19(28)29)21(15-8-10-16(23)11-9-15)25-22(24-20)26(3)32(4,30)31/h5,7-14,17,27H,6H2,1-4H3,(H,28,29)/b7-5+,13-12+/t17-/m1/s1

Beschreibung

Rosuvastatin Dehydro Acid (2E,5R,6E)-3-Dehydroxy Rosuvastatin is a process- and degradation-related impurity observed during synthesis and stability of rosuvastatin API. As a closely related dehydrolyzed species, it demands precise identification and quantification to uphold drug substance purity and regulatory expectations. Stability-indicating HPLC-UV and LC-MS methods provide routine detection and quantitation while NMR and HRMS support definitive structural confirmation. Effective impurity control relies on optimized reaction conditions, appropriate antioxidant use and controlled storage to minimize formation. Comprehensive characterization and forced degradation profiling guide specification setting, risk assessment and batch release decisions to protect potency and safety.