Seladelpar S-Sulfoxid ist das Sulfoxid-Oxidationsprodukt von Seladelpar und wird formal als oxidatives Prozess-Impurity sowie potenzieller Abbauindikator beschrieben, nicht als eigenständiger Pharmakophor. Mit der Summenformel C21H23F3O6S und einer Molekülmasse von 460.46 g/mol enthält es ein stereogenes Schwefelzentrum, das als konfigurationsrelevante Sulfoxid-Isomerie vorliegen kann. Die Entstehung ist typischerweise mit peroxidvermittelter Oxidation während Synthese, Lagerung oder Probenhandhabung verbunden. Charakterisierung und Gehaltsbestimmung erfordern in der Regel LC-MS/MS mit hochauflösender Massenspektrometrie, ergänzt durch HPLC-UV und, falls erforderlich, NMR zur Strukturabsicherung. Regulatorisch steht die Verunreinigungsprofilierung gemäß ICH Q3A/Q3B im Vordergrund.
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