2-cloroetilisocianato (CAS 1943-83-5) es una impureza clorada y altamente reactiva que puede aparecer como subproducto en síntesis de isocianatos y en procesos de cloroetilación. Su naturaleza electrófila favorece reacciones con nucleófilos | humedad y grupos activos | provocando degradación del producto y formación de carbamatos y dímeros. Desde el punto de vista analítico se detecta y cuantifica por GC-MS | HPLC con detección específica | FTIR y RMN 1H/13C | siendo crítico implementar controles de muestreo y trazabilidad. Por su toxicidad y sensibilidad a la hidrólisis | requiere manejo en atmósfera inerte | temperaturas bajas y métodos de neutralización validados para minimizar riesgos y contaminación cruzada.
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