Tetrahydro-2H-pyran-2-ol (2-Hydroxytetrahydropyran) | CAS 694-54-2 | es una impureza polar y hydroxilada que puede originarse en síntesis y procesos de protección de grupos funcionales; su presencia influye en la solubilidad y en el perfil de reactividad por su capacidad donadora y aceptora de enlaces de hidrógeno | complicando purificaciones y aumentando la retención en fases polares. Analíticamente se detecta y cuantifica por GC-MS | HPLC con detectores adecuados y RMN | y requiere control estricto por su impacto potencial en la estabilidad del producto y en los rendimientos. Su eliminación suele abordarse mediante destilación a vacío | extracción selectiva o adsorción en lecho fijo para cumplir especificaciones de calidad.
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