Avermectin B1 (CAS 71751-41-2) es una impureza crítica derivada de la mezcla de isómeros de abamectina que requiere control riguroso en procesos industriales. Presenta un perfil cromatográfico complejo con isómeros A1 y B1 parcialmente coeluyentes | solubilidad limitada en agua y susceptibilidad a oxidación y epimerización durante almacenamiento. Su cuantificación se realiza por HPLC con detección UV o por LC-MS/MS para identificación de trazas y determinación de límites de aceptación. Es esencial establecer especificaciones de impureza | pruebas de estabilidad forzada y condiciones de manejo para minimizar degradación y garantizar cumplimiento regulatorio y calidad del producto final.
Referencias
Chamkasem, Narong, et al. “Liquid Chromatographic Determination of Abamectin in Fruits and Vegetables.†Journal of AOAC INTERNATIONAL, vol. 76, no. 3, May 1993, pp. 691–94, https://doi.org/10.1093/jaoac/76.3.691.
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