Adrenaline Impurity 15 (HCl) es una impureza identificada en procesos de síntesis y formulación del clorhidrato de adrenalina | caracterizada por modificaciones en el anillo catecol y/o en la cadena aminoalquil | que afectan propiedades fisicoquímicas y actividad farmacológica. Su perfil analítico incluye un tiempo de retención cercano al compuesto principal en HPLC | masa molecular adyacente detectada por LC-MS y señales específicas en espectros NMR. La presencia puede deberse a reacciones de oxidación | transposición o contaminantes de materias primas. Se recomienda monitorizar mediante métodos validados HPLC-UV y LC-MS | establecer límites de aceptación y optimizar condiciones de síntesis para minimizar su formación.
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