Albuterol Related Compound F, también denominado clorhidrato de éter etílico de salbutamol, es una impureza de proceso relacionada con agonistas β2 y presenta fórmula molecular C15H26ClNO3 y peso molecular de 303,82 g/mol. La especie corresponde a la O-etilación del grupo hidroxilo fenólico del núcleo de salbutamol, compatible con un subproducto de síntesis por alquilación o con una impureza adventicia por reacción con agentes etilantes. Por su forma salina y su comportamiento de ionización, la evaluación a nivel traza suele requerir LC-MS/MS o LC-MS de alta resolución, con confirmación ortogonal mediante LC-UV o RMN en el perfil de impurezas. Su importancia es principalmente estructural y regulatoria dentro del control de impurezas de sustancias β2-agonistas.
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