Lercanidipine Inhouse Impurity D, también denominada dehydro lercanidipine, CAS 887769-34-8, es un análogo oxidado relacionado con el proceso o la degradación del bloqueador de canales de calcio de tipo dihidropiridina lercanidipino. La fórmula molecular C36H39N3O6 y la masa molecular de 609,71 g/mol son coherentes con una deshidrogenación formal del esqueleto principal, con cambio del estado de oxidación y del comportamiento cromatográfico. Estas impurezas suelen separarse mediante HPLC indicativa de estabilidad con detección por arreglo de diodos y confirmarse por LC-MS/MS, siendo la HRMS útil para la asignación elemental. Es pertinente en el perfil de impurezas conforme a ICH Q3A y Q3B.
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