Impureza derivada metoxi de Olaparib presenta modificación estructural en el anillo aromático que puede alterar perfil farmacocinético y actividad farmacológica; su identificación es crítica para control de calidad y cumplimiento regulatorio. Suele detectarse como pico de retención desplazado en cromatografía líquida y mostrar espectroscopía de masas y señales características en RMN compatibles con un grupo metoxi. Su presencia puede afectar la potencia del lote y la seguridad por metabolitos activos o desconocidos, por lo que se requiere evaluación de límite de aceptación, pruebas de estabilidad y estrategias analíticas robustas para su cuantificación y monitorización en materias primas y productos terminados.
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