Valsartan Ethyl Ester (CAS 1111177-30-0) es una impureza estructural del valsartán caracterizada por la esterificación etílica del grupo ácido carboxílico | conservando el núcleo biphenilo-tetrazólico y la porción valina etiléster. Esta impureza puede formarse por esterificación incompleta | transesterificación o control insuficiente de etapas de síntesis y purificación. Tiene relevancia analítica y regulatoria por su impacto en la pureza del API; su identificación y cuantificación típicamente se realizan por HPLC con detección UV | LC-MS y RMN 1H/13C. Las estrategias de control incluyen especificaciones de límite | optimización de condiciones de reacción y etapas de eliminación cromatográfica o de cristalización.
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