210289-73-9Amoxicillin Open RIng Trimer Impurity

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Catalogue No.:	VE009467
CAS No.:	210289-73-9
Mol. Formula:	C48H59N9O16S3
Mol. Weight:	1114.2 g/mol

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Additional information on CAS 210289-73-9

Parent drug

Amoxicillin

IUPAC Name

(2R,2’R,2 »R,4S,4’S,4 »S)-2,2′,2 »-((1R,4R,7R,10R,13R,16R)-16-amino-1-carboxylato-4,10,16-tris(4-hydroxyphenyl)-3,6,9,12,15-pentaoxo-2,5,8,11,14-pentaazahexadecane-1,7,13-triyl)tris(5,5-dimethylthiazolidine-4-carboxylate)

Synonyms

N/A

Description

Amoxicillin Open Ring Trimer Impurity, CAS 210289-73-9, is a high-molecular-weight process and degradation-related species associated with beta-lactam ring opening followed by oligomeric coupling of amoxicillin-derived fragments. With formula C48H59N9O16S3 and molecular weight 1114.2 g/mol, it represents a trimeric adduct rather than a simple hydrolytic product, and may arise during stress conditions, prolonged storage, or suboptimal synthesis control. Its structural complexity and low abundance typically require orthogonal characterization by LC-MS/MS, high-resolution MS, and impurity profiling by HPLC with diode array detection. As a non-classical related substance, it is evaluated within impurity control frameworks rather than nitrosamine-specific ICH M7 concern.

References

Amoxicillin Open RIng Trimer Impurity(CAS No: 210289-73-9) or (2R,2’R,2 »R,4S,4’S,4 »S)-2,2′,2′ – ((1R,4R,7R,10R,13R,16R)-16-amino-1-carboxylato-4,10,16-tris(4-hydroxyphenyl)-3,6,9,12,15-pentaoxo-2,5,8,11,14-pentaazahexadecane-1,7,13-triyl)tris(5,5-dimethylthiazolidine-4-carboxylate),it is a class of beta-lactam antimicrobials, it against gram-positive bacteria so it used antibiotics in the primary care by binding to penicillin-binding proteins.