2206825-87-6Apixaban Amino Acid Impurity

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Catalogue No.:	VL3170013
CAS No.:	2206825-87-6
Mol. Formula:	C25H27N5O5
Mol. Weight:	477.52 g/mol

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Additional information on CAS 2206825-87-6

Parent drug

Apixaban

IUPAC Name

5-((4-(3-carbamoyl-1-(4-methoxyphenyl)-7-oxo-1, 4, 5, 7-tetrahydro-6H-pyrazolo[3, 4-c]pyridin-6-yl)phenyl)amino)pentanoic acid

Pharmacopoeial Synonyms

N/A

Other Synonyms

Apixaban Open Ring Impurity; Apixaban Open Chain Acid Impurity; 5-[[4-[3-(Aminocarbonyl)-1,4,5,7-tetrahydro-1-(4-methoxyphenyl)-7-oxo-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl]amino]pentanoic Acid; 5-({4-[3-carbamoyl-1-(4-methoxyphenyl)-7-oxo-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}amino)pentanoic acid

Smiles

O=C(N(C1=CC=C(NCCCCC(O)=O)C=C1)CC2)C3=C2C(C(N)=O)=NN3C4=CC=C(OC)C=C4

InChI

InChI=1S/C25H27N5O5/c1-35-19-11-9-18(10-12-19)30-23-20(22(28-30)24(26)33)13-15-29(25(23)34)17-7-5-16(6-8-17)27-14-3-2-4-21(31)32/h5-12,27H,2-4,13-15H2,1H3,(H2,26,33)(H,31,32)

Description

Apixaban Amino Acid Impurity (CAS No: 2206825-87-6) or 5-((4-(3-carbamoyl-1-(4-methoxyphenyl)-7-oxo-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)phenyl)amino)pentanoic acid, it produces its antithrombotic effect by inhibiting free and clot-bound factor Xa and is used as Treatment And Prevention of Thromboembolic Disease.

References

Budovich, Aliaksandr, et al. “Role of Apixaban (Eliquis) in the Treatment and Prevention of Thromboembolic Disease.” Pharmacy and Therapeutics, vol. 38, no. 4, 1 Apr. 2013, pp. 206–231, www.ncbi.nlm.nih.gov/pmc/articles/PMC3684191/#b5-ptj3804206.