Donepezil N-Oxide
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120013-84-5Donepezil N-Oxide

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Catalogue No.:VL173008
CAS No.:120013-84-5
Mol. Formula:C24H29NO4
Mol. Weight:395.49 g/mol

Additional information on CAS 120013-84-5

Parent drug

Donepezil

IUPAC Name

2, 3-Dihydro-5, 6-dimethoxy-2-[[cis/trans-1-oxido-1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one

Pharmacopoeial Synonyms

N/A

Other Synonyms

rac (cis/trans) Donepezil N-Oxide; 2-[(1-benzyl-1-oxidopiperidin-1-ium-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one; 1H-Inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-((trans-1-oxido-1-(phenylmethyl)-4-piperidinyl)methyl)-

Smiles

COC1=C(C=C2C(=C1)CC(C2=O)CC3CC[N+](CC3)(CC4=CC=CC=C4)[O-])OC

InChI

InChI=1S/C24H29NO4/c1-28-22-14-19-13-20(24(26)21(19)15-23(22)29-2)12-17-8-10-25(27,11-9-17)16-18-6-4-3-5-7-18/h3-7,14-15,17,20H,8-13,16H2,1-2H3 IUPAC–2-[(1-benzyl-1-oxidopiperidin-1-ium-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one

Description

Donepezil N-Oxide, is a meticulously characterized reference material that complies with rigorous regulatory requirements, including those defined by USP, EMA, JP, and BP. This product plays a crucial role in Abbreviated New Drug Applications (ANDA), New Drug Applications (NDA), and the commercial manufacturing of Donepezil. It is further supported by a detailed Structure Elucidation Report (SER), ensuring high accuracy and reliability across a broad range of analytical applications. Donepezil N-Oxide (CAS No.: 120013-84-5) is an impurity present in the formulation of Donepezil hydrochloride which is a new anti-Alzheimer drug. It is the robust acetylcholine esterase inhibitor and has a significantly greater grade of selectivity of AChE in the central nervous system.

References

Sreelatha, P., et al.

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