121-30-2Hydrochlorothiazide EP Impurity B

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Catalogue No.:	VL80003
CAS No.:	121-30-2
Mol. Formula:	C6H8ClN3O4S2
Mol. Weight:	285.73 g/mol

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Additional information on CAS 121-30-2

Parent drug

Hydrochlorothiazide/ Benzothiadiazine/ Altizide

IUPAC Name

4-Amino-6-chloro-m-benzenedisulfonamide

Characterization Data (Included)

HPLC, MASS/LC-MS, 1H NMR, FT-IR, Potency, and Structure Elucidation Report (SER).

Additional Characterization Data

QNMR, D2O Exchange, 13C NMR, 13C APT, COSY NMR, NOESY NMR, 15N NMR, HSQC NMR, HMQC NMR, and HMBC NMR. These are available upon request and may be free or subject to additional charges.

Pharmacopeial Synonyms

Altizide EP Impurity A; Hydrochlorothiazide Related Compound A; Benzothiadiazine Related Compound A; Salamide

Synonyms

Chloraminophenamide; 5(3)-Chloroaniline-2,4(4,6)-disulfonamide; 5-Chloro-2,4-bis(sulfonamide)aniline;3-Chloro-4,6-disulfamoylaniline

Smiles

Nc1cc(Cl)c(S(N)(=O)=O)cc1S(N)(=O)=O

Inchl

InChI=1S/C6H8ClN3O4S2/c7-3-1-4(8)6(16(10,13)14)2-5(3)15(9,11)12/h1-2H,8H2,(H2,9,11,12)(H2,10,13,14)

Description

Hydrochlorothiazide EP Impurity B, also designated hydrochlorothiazide related compound A, benzothiadiazine related compound A, Altizide EP Impurity A, and salamide, is a chlorinated benzothiadiazine sulfonamide impurity with CAS 121-30-2. Its molecular formula is C6H8ClN3O4S2 and molecular weight is 285.73 g/mol. Structurally, it represents a closely related synthetic or degradation-associated analog of thiazide diuretics, arising from incomplete cyclization, desulfonylative transformation, or route-specific side products. Because of its structural proximity to hydrochlorothiazide, trace-level characterization commonly relies on LC-MS/MS, HRMS, and orthogonal HPLC methods, with NMR confirmation when isolated. Its presence is relevant to impurity profiling and specification setting.