Propionyl-D-alanine, CAS 1309000-24-5, is the N-acylated D-amino acid corresponding to propionic acid condensation with D-alanine. With formula C6H11NO3 and molecular weight 145.16 g/mol, it is a small chiral amide impurity that may arise from acyl transfer, incomplete coupling, or stereochemical contamination during peptide or amino acid synthesis. The compound is not a nitrosamine, but its structure places it within the broader class of process-related synthetic impurities. Characterization commonly relies on LC-MS/MS, chiral HPLC, and NMR, with MS fragmentation supporting assignment of the amide linkage and D configuration.
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