(R)-3-Aminopiperidine dihydrochloride, CAS 334618-23-4, is the hydrochloride salt of a chiral saturated heterocycle bearing a primary amine at the 3-position. With molecular formula C5H14Cl2N2 and molecular weight 173.08 g/mol, it is commonly encountered as a process-related impurity or synthetic intermediate in piperidine chemistry, arising from incomplete stereochemical resolution or side reaction pathways during reductive amination and ring construction. Because it is a basic, polar amine, characterization typically relies on LC-MS/MS, HILIC-LC, and chiral separations, with GC-MS after derivatization when volatile profiling is required. Regulatory assessment focuses on impurity origin and enantiomeric integrity rather than intrinsic class-specific genotoxicity.
References
Petri, Antonella, et al. “Asymmetric Synthesis of a High Added Value Chiral Amine Using Immobilized o-Transaminases.” Beilstein Journal of Organic Chemistry, vol. 15, Jan. 2019, pp. 60–66, https://doi.org/10.3762/bjoc.15.6.
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