22503-74-8: 7-Chloro-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine 1,1-dioxide

Status: In-stock

It is one of impurity present in Hydrochlorothiazide. Hydrochlorothiazide is a thiazide diuretic, Hydrochlorothiazide acts on the proximal region of the distal convoluted tubule, inhibiting reabsorption by the sodium-chloride symporter, Inhibition of SLC12A3 reduces the magnitude of the concentration gradient between the epithelial cell and distal convoluted tubule, also reducing the reabsorption of water. Hydrochlorothiazide is transported from the circulation into epithelial cells of the distal convoluted tubule by the organic anion transporters OAT1, OAT3, and OAT4, transported to the lumen of the tubule by multidrug resistance-associated protein.

Additional information on CAS 22503-74-8

Catalogue No. VE009711
CAS No. 22503-74-8
Molecular Formula C7H7ClN2O2S
Molecular Weight 218.7 g/mol
Parent drug Hydrochlorothiazide
IUPAC Name 7-Chloro-3, 4-dihydro-2H-benzo[e][1, 2, 4]thiadiazine 1, 1-dioxide
Synonyms N/A
References Vongpatanasin, W. (2015). Hydrochlorothiazide is not the most useful nor versatile thiazide diuretic. Current Opinion in Cardiology, 30(4), 361–365. https://doi.org/10.1097/hco.0000000000000178
Status In-stock

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22503-74-8: 7-Chloro-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine 1,1-dioxide

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