1449510-64-8: Apixaban Inhouse Impurity E
Apixaban Inhouse Impurity E (CAS No: 1449510-64-8) or 6-(4-(5-Chloropentanamido)phenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide, is a selective factor Xa inhibitor by Inhibition of factor Xa leads to decreased conversion of factor II (prothrombin) to IIa, resulting in decreased thrombin generation used in help prevent strokes or blood clots.
Additional information on CAS 1449510-64-8
VE008156
1449510-64-8
C25H26ClN5O4
495.96 g/mol
Apixaban
6-(4-(5-Chloropentanamido)phenyl)-1-(4-methoxyphenyl)-7-oxo-4, 5, 6, 7-tetrahydro-1H-pyrazolo[3, 4-c]pyridine-3-carboxamide
Apixaban Impurity 19
O=C(N(C1=CC=C(NC(CCCCCl)=O)C=C1)CC2)C3=C2C(C(N)=O)=NN3C4=CC=C(OC)C=C4
Budovich, Aliaksandr, et al. “Role of Apixaban (Eliquis) in the Treatment and Prevention of Thromboembolic Disease.” Pharmacy and Therapeutics, vol. 38, no. 4, 1 Apr. 2013, pp. 206–231, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3684191/#b5-ptj3804206.
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