Bicalutamide JP Related substance PÂ is an impurity present in Bicalutamide, Bicalutamide is an androgen receptor inhibitor, Bicalutamide competes with androgen for the binding of androgen receptors, consequently blocking the action of androgens of adrenal and testicular origin which stimulate the growth of normal and malignant prostatic tissue, which is used to treat Stage d2 metastatic carcinoma of the prostate.
References
Chen, K.-C., Chen, C.-R., Chen, C.-Y., Tzou, K.-Y., Peng, C.-C., & Peng, R. Y. (2020). Bicalutamide Elicits Renal Damage by Causing Mitochondrial Dysfunction via ROS Damage and Upregulation of HIF-1. International Journal of Molecular Sciences, 21(9), 3400. https://doi.org/10.3390/ijms21093400 ‌‌ ‌
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