Bisoprolol Phosphomonoester
It is an impurity present in Bisoprolol, Bisoprolol is a beta-1 adrenergic blocking agent, When β1 receptors are activated by adrenergic neurotransmitters such as epinephrine both the blood pressure and heart rate increase, which leads to greater cardiovascular work and increases the oxygen demand. Bisoprolol reduces cardiac workload by decreasing contractility and the need for oxygen through competitive inhibition of β1 adrenergic receptors and also reduces the output of renin in the kidneys, which normally increases blood pressure. central nervous system effects of bisoprolol by diminishing sympathetic nervous system output from the brain, decreasing blood pressure and heart rate.
Additional information on Bisoprolol Phosphomonoester
VE009761
N/A
C18H32NO7P
405.43 g/mol
Bisoprolol
1-(4-((2-isopropoxyethoxy)methyl)phenoxy)-3-(isopropylamino)propan-2-yl dihydrogen phosphate
N/A
Metra, M., Nodari, S., Bordonali, T., Milani, P., Lombardi, C., Bugatti, S., … Dei Cas, L. (2007). Bisoprolol in the treatment of chronic heart failure: from pathophysiology to clinical pharmacology and trial results. Therapeutics and Clinical Risk Management, 3(4), 569–578. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374926/
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