Celecoxib Impurity 11

It is one of impurity present in Celecoxib, Celecoxib is a selective cyclooxygenase-2 inhibitor, By inhibiting prostaglandin synthesis non-steroidal anti-inflammatory drugs cause mucosal damage and ulceration. Celecoxib poses less of an ulceration risk than other NSAIDS, owing to its decreased effect on gastric mucosal prostaglandin synthesis when compared to placebo, also exerts anticancer effects by binding to the cadherin-11 protein, which is involved in the progression of tumors and inhibiting the 3 phosphoinositide-dependent kinase-1 signaling mechanism, which is used to treat osteoarthritis, rheumatoid arthritis, and to reduce polyps in familial adenomatous polyposis.

Additional information on Celecoxib Impurity 11

Catalogue No.

VE007646

CAS No.

N/A

Molecular Formula

C11H8F3N3O

Molecular Weight

255.2 g/mol

Parent drug

Celecoxib

IUPAC Name

1-Nitroso-5-(p-tolyl)-3-(trifluoromethyl)-1H-pyrazole

Synonyms

N/A

References

Xu, C., Gu, K., Yasen, Y., & Hou, Y. (2016). Efficacy and Safety of Celecoxib Therapy in Osteoarthritis. Medicine, 95(20), e3585. https://doi.org/10.1097/md.0000000000003585

Status

In-stock