1061214-09-2: Celecoxib Impurity 5
It is an impurity present in Celecoxib. Celecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor, which is a nonsteroidal anti-inflammatory drug, COX-2 is inflamed tissues, and it is induced by inflammatory mediators. inhibition of this enzyme reduces the synthesis of metabolites that include prostaglandin E2, prostacyclin, thromboxane, prostaglandin D2 and prostaglandin F2 inhibition of these mediators leads to the alleviation of pain and inflammation. Celecoxib poses less of an ulceration risk than other NSAIDS, owing to its decreased effect on gastric mucosal prostaglandin synthesis, which is used to treat osteoarthritis, rheumatoid arthritis, acute pain, and menstrual symptoms.
Additional information on CAS 1061214-09-2
VE006161
1061214-09-2
C17H15F3N2O3S
384.37 g/mol
Celecoxib
4-[[3-(4-Methylphenyl)-3-oxo-1-(trifluoromethyl)propylidene]amino]benzenesulfonamide
N/A
Gong, L., Thorn, C. F., Bertagnolli, M. M., Grosser, T., Altman, R. B., & Klein, T. E. (2012). Celecoxib pathways. Pharmacogenetics and Genomics, 22(4), 310–318. https://doi.org/10.1097/fpc.0b013e32834f94cb
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