1061214-09-2: Celecoxib Impurity 5

It is an impurity present in Celecoxib. Celecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor, which is a nonsteroidal anti-inflammatory drug, COX-2 is inflamed tissues, and it is induced by inflammatory mediators. inhibition of this enzyme reduces the synthesis of metabolites that include prostaglandin E2, prostacyclin, thromboxane, prostaglandin D2 and prostaglandin F2 inhibition of these mediators leads to the alleviation of pain and inflammation. Celecoxib poses less of an ulceration risk than other NSAIDS, owing to its decreased effect on gastric mucosal prostaglandin synthesis, which is used to treat osteoarthritis, rheumatoid arthritis, acute pain, and menstrual symptoms.

Additional information on CAS 1061214-09-2

Catalogue No.

VE006161

CAS No.

1061214-09-2

Molecular Formula

C17H15F3N2O3S

Molecular Weight

384.37 g/mol

Parent drug

Celecoxib

IUPAC Name

4-[[3-(4-Methylphenyl)-3-oxo-1-(trifluoromethyl)propylidene]amino]benzenesulfonamide

Synonyms

N/A

References

Gong, L., Thorn, C. F., Bertagnolli, M. M., Grosser, T., Altman, R. B., & Klein, T. E. (2012). Celecoxib pathways. Pharmacogenetics and Genomics, 22(4), 310–318. https://doi.org/10.1097/fpc.0b013e32834f94cb

Status

In-stock

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1061214-09-2: Celecoxib Impurity 5

1061214-09-2: Celecoxib Impurity 5
Catalogue No.

VE006161

CAS No.

1061214-09-2

Molecular Formula

C17H15F3N2O3S

Molecular Weight

384.37 g/mol

Parent drug

Celecoxib

IUPAC Name

4-[[3-(4-Methylphenyl)-3-oxo-1-(trifluoromethyl)propylidene]amino]benzenesulfonamide

Synonyms

N/A

References

Gong, L., Thorn, C. F., Bertagnolli, M. M., Grosser, T., Altman, R. B., & Klein, T. E. (2012). Celecoxib pathways. Pharmacogenetics and Genomics, 22(4), 310–318. https://doi.org/10.1097/fpc.0b013e32834f94cb

Status

In-stock

ListName

Celecoxib Impurity 5

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