Stock Locations

New Jersey, USA
Czech Republic, EU
Mumbai, India

* Stock subject to availability.

Documentation

Download MSDS

Download Sample COA

Includes: HPLC, MASS/LC-MS, 1H NMR, FT-IR, Potency, Structure Elucidation Report (SER), and additional analytical data depending on the product.

3077185-45-3Eltrombopag Ethyl Ester Impurity

● In Stock

Catalogue No.:	VE0028252
CAS No.:	3077185-45-3
Mol. Formula:	C27H26N4O4
Mol. Weight:	470.52 g/mol

Request a quote

Add to RFQ list

Additional information on CAS 3077185-45-3

Parent drug

Eltrombopag

IUPAC Name

(ethyl (Z)-3′-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)hydrazinyl)-2′-hydroxy-[1,1′- biphenyl]-3-carboxylate)

Pharmacopeial Synonyms

N/A

Synonyms

N/A

Smiles

O=C(C1=CC=CC(C2=CC=CC(N/N=C3C(C)=NN(C4=CC(C)=C(C)C=C4)C/3=O)=C2O)=C1)OCC

InChI

InChI=1S/C27H26N4O4/c1-5-35-27(34)20-9-6-8-19(15-20)22-10-7-11-23(25(22)32)28-29-24-18(4)30-31(26(24)33)21-13-12-16(2)17(3)14-21/h6-15,28,32H,5H2,1-4H3/b29-24-

Description

Eltrombopag Ethyl Ester Impurity (CAS 3077185-45-3) is a process-related impurity arising from ethyl esterification steps of eltrombopag synthesis that requires focused control within the API impurity profile. This impurity can compromise drug substance purity and long term stability and is typically monitored by validated HPLC-UV assays supported by LC-MS for mass confirmation and NMR for structural assignment. Effective control is achieved through optimized reaction conditions, targeted purification and in-process controls to minimize formation and carryover. Establishing qualification thresholds, stability indicating methods and documentation in line with ICH guidelines ensures robust identification, quantitation and regulatory compliance.