EsCitalopram N-Desmethyl (Free Base)
It is one of impurity present in EsCitalopram, Escitalopram is a selective serotonin reuptake inhibitor, which enhances serotonergic activity by binding to the orthosteric binding site on the serotonin transporter, the same site to which endogenous 5-HT binds and thus prevents the reuptake of serotonin into the presynaptic neuron. It binds to a secondary allosteric site on the SERT molecule to inhibit 5-HT reuptake more. sustained elevation of synaptic 5HT eventually causes desensitization of 5-HT1A auto-receptors, which normally endogenous 5-HT release in the presence of excess 5-HT, this desensitization is needed for the clinical effect of SSRIs and is responsible for their typically prolonged onset of action
Additional information on EsCitalopram N-Desmethyl (Free Base)
VE006634
N/A
C19H19FN2O
310.4 g/mol
Escitalopram
(S)-1-(4'-Fluorophenyl)-1-(3-(methylamino)propyl)-1, 3-dihydroisobenzo furan-5-carbonitrile
N/A
Landy, K., Rosani, A., & Estevez, R. (2022, October 9). Escitalopram. Retrieved November 4, 2022, from Nih.gov website: https://www.ncbi.nlm.nih.gov/books/NBK557734/
In-stock
