N (4)-hydroxycytidine (CAS No: 3258-02-4) is an antiviral ribonucleoside analog that acts as a competitive alternative substrate for virally encoded RNA-dependent RNA polymerases. It has shown broad-spectrum antiviral activity against viruses in the Flaviviridae, Coronaviridae, and Orthomyxoviridae families.
1-[(2R, 3R, 4S, 5R)-3, 4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-(hydroxyamino)pyrimidin-2-one
Agostini, Maria L., et al. “Small-Molecule Antiviral v- D – N 4 -Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance.” Journal of Virology, edited by Tom Gallagher, vol. 93, no. 24, Dec. 2019, https://doi.org/10.1128/jvi.01348-19. Sticher, Zachary M., et al. “Analysis of the Potential for N 4 -Hydroxycytidine to Inhibit Mitochondrial Replication and Function.” Antimicrobial Agents and Chemotherapy, vol. 64, no. 2, Jan. 2020, https://doi.org/10.112