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763114-26-7Olaparib Impurity 33

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Catalogue No.:	VE0018355
CAS No.:	763114-26-7
Mol. Formula:	C16H11FN2O3
Mol. Weight:	298.27 g/mol

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Additional information on CAS 763114-26-7

Parent drug

Olaparib

IUPAC Name

2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid

Pharmacopeial Synonyms

N/A

Synonyms

N/A

Smiles

O=C(O)C1=CC(CC2=NNC(C3=C2C=CC=C3)=O)=CC=C1F

InChI

InChI=1S/C16H11FN2O3/c17-13-6-5-9(7-12(13)16(21)22)8-14-10-3-1-2-4-11(10)15(20)19-18-14/h1-7H,8H2,(H,19,20)(H,21,22)

Description

Olaparib Impurity 33 (CAS 763114-26-7) is a structurally defined small-molecule process impurity associated with the pyridazine-based PARP inhibitor olaparib. With molecular formula C16H11FN2O3 and molecular weight 298.27 g/mol, it represents a fluorinated aromatic heterocycle bearing carbonyl and heteroatom functionality consistent with a synthetic byproduct or transformation product arising during route-specific intermediate coupling or oxidative degradation. Its assessment is typically supported by LC-MS/MS, high-resolution mass spectrometry, and orthogonal HPLC-UV characterization, with NMR used for structure confirmation. Although not a classic genotoxic alert class, its impurity profile is considered within the framework of ICH Q3A and, when relevant, ICH M7.