Remdesivir IP Impurity B
Remdesivir IP Impurity B or (3aR,4R,6R,6aR)-4-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-6-(hydroxymethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole-4-carbonitrile,is a phosphoramidite prodrug and a free 3′-hydroxyl group that allows for continued chain elongation that used to treat RNA virus.
Additional information on Remdesivir IP Impurity B
(3aR, 4R, 6R, 6aR)-4-(4-aminopyrrolo[2, 1-f][1, 2, 4]triazin-7-yl)-6-(hydroxymethyl)-2, 2-dimethyltetrahydrofuro[3, 4-d][1, 3]dioxole-4-carbonitrile
Eastman, Richard T., et al. “Remdesivir: A Review of Its Discovery and Development Leading to Emergency Use Authorization for Treatment of COVID-19.” ACS Central Science, vol. 6, no. 5, May 2020, pp. 672–83, https://doi.org/10.1021/acscentsci.0c00489. ?
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