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2618647-80-4Semaglutide Impurity 131

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Catalogue No.:	VE0026013
CAS No.:	2618647-80-4
Mol. Formula:	C71H107N5O16
Mol. Weight:	1286.6 g/mol

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Additional information on CAS 2618647-80-4

Parent drug

Semaglutide

IUPAC Name

Tert-butyl 18-[[(2S)-5-[2-[2-[2-[2-[2-[2-[[(5S)-5-(9H-fluoren-9-ylmethoxycarbonylamino)-6-oxo-6-phenylmethoxyhexyl]amino]-2-oxoethoxy]ethoxy]ethylamino]-2-oxoethoxy]ethoxy]ethylamino]-1-[(2-methylpropan-2-yl)oxy]-1,5-dioxopentan-2-yl]amino]-18-oxooctadecanoate

Pharmacopeial Synonyms

N/A

Synonyms

N/A

Smiles

CC(C)(OC(CCCCCCCCCCCCCCCCC(N[C@H](C(OC(C)(C)C)=O)CCC(NCCOCCOCC(NCCOCCOCC(NCCCC[C@H](NC(OCC1C2=CC=CC=C2C3=CC=CC=C13)=O)C(OCC4=CC=CC=C4)=O)=O)=O)=O)=O)=O)C

InChI

InChI=1S/C71H107N5O16/c1-70(2,3)91-66(81)38-23-18-16-14-12-10-8-7-9-11-13-15-17-22-37-63(78)75-61(68(83)92-71(4,5)6)39-40-62(77)73-42-44-85-46-49-88-53-65(80)74-43-45-86-47-48-87-52-64(79)72-41-29-28-36-60(67(82)89-50-54-30-20-19-21-31-54)76-69(84)90-51-59-57-34-26-24-32-55(57)56-33-25-27-35-58(56)59/h19-21,24-27,30-35,59-61H,7-18,22-23,28-29,36-53H2,1-6H3,(H,72,79)(H,73,77)(H,74,80)(H,75,78)(H,76,84)/t60-,61-/m0/s1

Description

Semaglutide Impurity 131 (CAS 2618647-80-4) is a characterized process-related peptide impurity associated with semaglutide synthesis. Detected at trace levels by reversed-phase HPLC and confirmed by LC-MS and peptide mapping, this impurity can arise from incomplete coupling or side-chain modification during solid-phase synthesis. Its presence is critical for quality control as it may affect product purity, potency and stability and requires monitoring per ICH impurity guidelines. Availability of reference material facilitates method validation, limits setting, and degradation studies. Analytical strategies include high-resolution MS, orthogonal chromatography and forced-degradation profiling to ensure robust detection and control.