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Documentation

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Includes: HPLC, MASS/LC-MS, 1H NMR, FT-IR, Potency, Structure Elucidation Report (SER), and additional analytical data depending on the product.

Semaglutide Impurity 140

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Catalogue No.:	VE0025995
CAS No.:	N/A
Mol. Formula:	C10H17NO8
Mol. Weight:	279.24 g/mol

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Additional information on

Parent drug

Semaglutide

IUPAC Name

2-[2-[2-[[2-(carboxymethoxy)acetyl]amino]ethoxy]ethoxy]acetic acid

Smiles

O=C(O)COCC(NCCOCCOCC(O)=O)=O

InChI

InChI=1S/C10H17NO8/c12-8(5-19-7-10(15)16)11-1-2-17-3-4-18-6-9(13)14/h1-7H2,(H,11,12)(H,13,14)(H,15,16)

Description

Semaglutide Impurity 140 is a structurally related peptide variant observed during synthesis or storage of semaglutide. It presents as a minor sequence or modification-related species with measurable retention time shift in reverse phase HPLC and a characteristic mass difference by LC-MS, necessitating targeted quantitation in quality control workflows. Formation pathways include incomplete coupling, side-chain modification and low-level degradation under forced stress conditions. Impurity profiling, peptide mapping and orthogonal MS/MS fragmentation confirm identity and inform control strategy. Monitoring under ICH stability and specification guidelines is recommended to ensure safety, potency and batch-to-batch consistency.