Trazodone BP Impurity E
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1346599-35-6Trazodone BP Impurity E

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Catalogue No.:VL620005
CAS No.:1346599-35-6
Mol. Formula:C21H26ClN5O
Mol. Weight:399.92 g/mol

Additional information on CAS 1346599-35-6

Parent drug

Trazodone

IUPAC Name

2-3-[4-(3-Chloro-4-ethylphenyl)piperazin-1-yl]propyl-1,2,4-triazolo[4,3-a]pyridin-3(2H)-one

Synonyms

Trazodone 4-Ethyl Impurity; Trazodone 4-Ethyl Impurity; 2-[3-[4-(3-Chloro-4-ethylphenyl)-1-piperazinyl]propyl]-1, 2, 4-triazolo[4, 3-a]pyridin-3(2H)-one;

Description

Trazodone BP Impurity E, also designated Trazodone 4-Ethyl Impurity, corresponds to a structurally related process-related impurity of trazodone, CAS 1346599-35-6. With molecular formula C21H26ClN5O and molecular weight 399.92 g/mol, it retains the triazolopyridinyl and chlorophenyl motifs characteristic of the parent scaffold while bearing an ethyl-substituted side-chain variant. Such impurities are typically associated with incomplete alkylation, side-chain rearrangement, or minor synthetic route deviations. Characterization generally requires LC-MS/MS for selective detection and structural assignment, with complementary HPLC-UV and, where necessary, high-resolution MS to support impurity profiling under pharmacopeial and ICH Q3A/Q3B expectations.

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