2’S-α-Fluoro tribenzoyl sofosbuvir intermidiate is an impurity present in sofosbuvir, Sofosbuvir is metabolized into its active form as the antiviral agent 2'-deoxy-2'-α-fluoro-β-C-methyluridine-5'-triphosphate, which is used in combination therapy with other antiviral medications to treat chronic hepatitis C virus (HCV) infected patients with HCV genotypes 1-6, and to treat HCV and HIV, co-infected patients.
References
Bhatia, H. K., Singh, H., Grewal, N., & Natt, N. K. (2014). Sofosbuvir: A novel treatment option for chronic hepatitis C infection. Journal of Pharmacology and Pharmacotherapeutics, 5(4), 278–284. https://doi.org/10.4103/0976-500x.142464
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