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内容: HPLC、MASS/LC-MS、1H NMR、FT-IR、含量、構造解析レポート（SER）、および製品に応じた追加分析データ。

2517964-85-9Abiraterone Acetate N-Oxide

● Under Development

カタログ番号:	VL830049
CAS番号:	2517964-85-9
分子式:	C26H33NO3
分子量:	407.55 g/mol

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に関する追加情報 CAS 2517964-85-9

親薬物

Abiraterone

IUPAC名

3-((3S, 8R, 9S, 10R, 13S, 14S)-3-acetoxy-10, 13-dimethyl-2, 3, 4, 7, 8, 9, 10, 11, 12, 13, 14, 15-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)pyridine 1-oxide

薬局方同義語

N/A

Other Synonyms

17-(Pyridin-3-yl)androsta-5,16-dien-3Î²-yl Acetate N-oxide

SMILES

C[C@@]12C(C3=C[N+]([O-])=CC=C3)=CC[C@@]1([H])[C@]4([H])CC=C5C[C@@H](OC(C)=O)CC[C@]5(C)[C@@]4([H])CC2

InChI

InChI=1S/C26H33NO3/c1-17(28)30-20-10-12-25(2)19(15-20)6-7-21-23-9-8-22(18-5-4-14-27(29)16-18)26(23,3)13-11-24(21)25/h4-6,8,14,16,20-21,23-24H,7,9-13,15H2,1-3H3/t20-,21-,23-,24-,25-,26+/m0/s1

説明

Abiraterone Acetate N-Oxide is an impurity of Abiraterone acetate that is a prodrug used in castration-resistant prostate cancer by getting converted in vivo to abiraterone that acts by an androgen biosynthesis inhibition. It affects cancerous tissue as well as the natural synthesis of androgens.

References

Mach, Samuel, et al. â€œEpoxidation Is the Preferred Pathway of First-Stage Metabolism of Abiraterone Acetate in Brown Bullhead (Ameiurus Nebulosus).â€ Environmental Science and Pollution Research, vol. 26, no. 34, Oct. 2019, pp. 34896â€“904, https://doi.org/10.1007/s11356-019-06568-y. ?