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内容: HPLC、MASS/LC-MS、1H NMR、FT-IR、含量、構造解析レポート（SER）、および製品に応じた追加分析データ。

2484719-26-6Beta-Epoxyabiraterone Acetate

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カタログ番号:	VE006954
CAS番号:	2484719-26-6
分子式:	C26H33NO3
分子量:	407.5 g/mol

見積もり依頼

RFQリストに追加

に関する追加情報 CAS 2484719-26-6

親薬物

Abiraterone

IUPAC名

17-(Pyridin-3-yl)-16β,17β-epoxyandrost-5-en-3β-yl acetate

薬局方同義語

N/A

Other Synonyms

[(1R,2S,4S,6S,7S,10S,11R,14S)-7,11-dimethyl-6-pyridin-3-yl-5-oxapentacyclo[8.8.0.02,7.04,6.011,16]octadec-16-en-14-yl] acetate

Smile

CC(=O)O[C@H]1CC[C@@]2([C@H]3CC[C@]4([C@H]([C@@H]3CC=C2C1)C[C@@H]5[C@]4(O5)C6=CN=CC=C6)C)C

InChI

InChI=1S/C26H33NO3/c1-16(28)29-19-8-10-24(2)17(13-19)6-7-20-21(24)9-11-25(3)22(20)14-23-26(25,30-23)18-5-4-12-27-15-18/h4-6,12,15,19-23H,7-11,13-14H2,1-3H3/t19-,20+,21-,22-,23+,24-,25-,26+/m0/s1

説明

Beta-epoxyabiraterone acetate , also known as [(1R,2S,4S,6S,7S,10S,11R,14S)-7,11-dimethyl-6-pyridin-3-yl-5-oxapentacyclo[8.8.0.02,7.04,6.011,16]octadec-16-en-14-yl] acetate is a highly characterized reference material. It fully complies with stringent regulatory standards, including those set by USP, EMA, JP, and BP. This product is essential for use in Abbreviated New Drug Applications (ANDA), New Drug Applications (NDA), and the commercial production of Abiraterone. Moreover, it comes with a detailed Structure Elucidation Report (SER), ensuring its accuracy and reliability for a wide range of analytical applications. It is a metabolite of Abiraterone acetate that is a derivative of steroidal progesterone and is used in the treatment of metastatic castration (mCRPC) and treatment of metastatic high-risk castration-sensitive prostate cancer.

References

Kavitapu, DasameswaraRao, et al. â€œNew Stability Indicating RP-HPLC Method for the Determination of Abiraterone Acetate, Its Related Substances and Degradation Products in Bulk and Dosage Form.â€ Materials Today: Proceedings, vol. 34, 2021, pp. 469â€“78, https://doi.org/10.1016/j.matpr.2020.02.665. ?Mach, Samuel, et al. â€œEpoxidation Is the Preferred Pathway of First-Stage Metabolism of Abiraterone Acetate in Brown Bullhead (Ameiurus Nebulosus).â€ Environmental Science and Pollution Research, vol. 26