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内容: HPLC、MASS/LC-MS、1H NMR、FT-IR、含量、構造解析レポート（SER）、および製品に応じた追加分析データ。

1255529-25-9Edoxaban Impurity 10

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カタログ番号:	VE008121
CAS番号:	1255529-25-9
分子式:	C24H30ClN7O4S
分子量:	548.06 g/mol

見積もり依頼

RFQリストに追加

に関する追加情報 CAS 1255529-25-9

親薬物

Edoxaban

IUPAC名

N1-(5-chloropyridin-2-yl)-N2-((1R, 2S, 4S)-4-(dimethylcarbamoyl)-2-(5-methyl-4, 5, 6, 7-tetrahydrothiazolo[5, 4-c]pyridine-2-carboxamido)cyclohexyl)oxalamide

薬局方同義語

N/A

Other Synonyms

Edoxaban (RSS)-Isomer

SMILES

O=C(NC1=NC=C(Cl)C=C1)C(N[C@H]2[C@@H](NC(C(S3)=NC4=C3CN(C)CC4)=O)C[C@@H](C(N(C)C)=O)CC2)=O

InChI

InChI=1S/C24H30ClN7O4S/c1-31(2)24(36)13-4-6-15(27-20(33)21(34)30-19-7-5-14(25)11-26-19)17(10-13)28-22(35)23-29-16-8-9-32(3)12-18(16)37-23/h5,7,11,13,15,17H,4,6,8-10,12H2,1-3H3,(H,27,33)(H,28,35)(H,26,30,34)/t13-,15+,17-/m0/s1

説明

The Edoxaban Impurity 10 is a well-characterized reference material that meets stringent regulatory standards set by USP, EMA, JP, and BP. It plays a key role in Abbreviated New Drug Applications (ANDA), New Drug Applications (NDA), and the commercial production of Edoxaban. Edoxaban Impurity 10 or Edoxaban (RSS)-Isomer (CAS No.1255529-25-9) or N1-(5-chloropyridin-2-yl)-N2-((1R,2S,4S)-4-(dimethylcarbamoyl)-2-(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamido)cyclohexyl)oxalamide. Factor Xa of coagulation cascade is a attractive target for anticoagulant treatment. Edoxaban is a oral direct factor Xa inhibitor.

References

“Noor, Jesmin I., et al. â€œEdaravone Inhibits Lipid Peroxidation in Neonatal Hypoxic-Ischemic Rats: An in Vivo Microdialysis Study.â€ Neuroscience Letters, vol. 414, no. 1, Feb. 2007, pp. 5â€“9, https://doi.org/10.1016/j.neulet.2006.10.024. ?”