L-チロシンは、Levodopa EP Impurity B および Phenylalanine EP Impurity C とも呼ばれる芳香族アミノ酸で、4-ヒドロキシ-L-フェニルアラニンに相当する。CAS 60-18-4、分子式 C9H11NO3、分子量 181.07 g/mol である。構造的には、フェニルアラニン骨格のp位が水酸化された誘導体であり、生合成および分解の両面でカテコールアミン前駆体と密接に関連する。薬局方的には、レボドパやフェニルアラニン製造における不完全反応、加水分解、酸化変換に由来する工程関連不純物として現れることがある。検出と定量には、LC-MS/MS、LC-UV、微量では高分解能MSやキラルLCが一般に用いられる。
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