3-Amino-1-Propanol; Cyclophosphamide USP Related Compound E; 1-Amino-3-hydroxypropane;3-Propanolamine;beta-Alaninol;N-(3-Hydroxypropyl)amine;Dexpanthenol EP Impurity A;
설명
사이클로포스파미드 EP 불순물 G는 3-아미노-1-프로판올에 해당하며, CAS 156-87-6, 분자식 C3H9NO, 분자량 75.11 g/mol이다. 이 물질은 극성의 저분자 알카놀아민으로, 사이클로포스파미드 제조 공정에서 유래하는 공정 관련 불순물이거나 아미노알킬 중간체의 가수분해성 절단 산물일 수 있다. 니트로사민은 아니지만, 유도체화 아티팩트를 유발할 수 있고 아민화 단계 또는 알코올계 원료의 관리 불충분을 시사하므로 불순물 프로파일에서 의미가 있다. 극미량 정량에는 일반적으로 GC-MS 또는 LC-MS/MS가 요구되며, 보유력, 이온화, 선택성을 향상시키기 위해 전컬럼 유도체화가 자주 적용된다.
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