3-Amino-1-Propanol; Cyclophosphamide USP Related Compound E; 1-Amino-3-hydroxypropane;3-Propanolamine;beta-Alaninol;N-(3-Hydroxypropyl)amine;Dexpanthenol EP Impurity A;
説明
シクロホスファミド EP 不純物 G は 3-アミノ-1-プロパノールに相当し，CAS 156-87-6，分子式 C3H9NO，分子量 75.11 g/mol である。これは極性の高い低分子量アルカノールアミンであり，シクロホスファミド製造工程に由来する工程関連不純物，またはアミノアルキル中間体の加水分解的断片化に関連しうる。不純物としてはニトロソアミンではないが，誘導体化アーティファクトの要因となり，アミノ化工程やアルコール含有原料の管理不十分を示唆するため，プロファイル上重要である。微量定量には通常，保持性，イオン化，選択性を高めるための前処理誘導体化を伴う GC-MS または LC-MS/MS が用いられる。
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