Prucalopride Succinate Impurity – 2는 4-Amino-5-chloro-2,3-dihydrobenzofuran-7-carboxylic acid, CAS 123654-26-2를 의미하며, 분자식은 C9H8ClNO3, 분자량은 213.62 g/mol이다. 이 화합물은 헤테로방향족 아미노벤조푸란 카복실산으로, 프루칼로프라이드 골격 형성 과정에서 기능기 전환이 불완전할 때 발생하는 공정 관련 중간체 또는 합성 부산물과 부합한다. 염소화된 방향족 아민 유사 구조는 미량 존재 시에도 ICH M7 원칙에 따른 독성학적 평가가 요구될 수 있어 주의가 필요하다. 일반적으로 LC-MS/MS, 고분해능 LC-MS 및 보조적 HPLC-UV로 분석하며, 구조 확증을 위해 NMR이 추가될 수 있다.
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